Predominant enhancement of apoptosis induced by methyl jasmonate in bladder cancer cells: therapeutic effect of the Antp-conjugated Smac peptide.

Xing-yuan Xiao, Guo-song Jiang, Liang Wang, Lei Lv, Fu-Qing Zeng

Department of Urology, Wuhan Union Hospital, Huazhong University of Science and Technology, Hubei Province, China.

Anti-cancer drugs 2011 Oct

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Methyl jasmonate (MJ) has recently attracted attention as a promising antitumoral compound because of its highly specific proapoptotic properties in a wide range of malignancies. However, the high doses required to achieve a therapeutic benefit have limited its clinical development. Here, we hypothesize that the family of inhibitor of apoptosis proteins (IAPs) may inhibit MJ-mediated apoptosis in cancer cells. We combined MJ with the IAPs inhibitor, the second mitochondria-derived activator of caspases (Smac) peptide to treat bladder cancer cells. The results showed that the combination of MJ and Smac peptide enhanced the apoptosis-inducing effect in a synergistic manner by releasing and activating IAPs-bounding caspase-3. These findings suggest that the inhibition of IAPs could overcome the resistance of cancer cells to MJ.

Citation

Xing-yuan Xiao, Guo-song Jiang, Liang Wang, Lei Lv, Fu-Qing Zeng. Predominant enhancement of apoptosis induced by methyl jasmonate in bladder cancer cells: therapeutic effect of the Antp-conjugated Smac peptide. Anti-cancer drugs. 2011 Oct;22(9):853-63