Seth A Johnson, Katharine J Harmon, Sarah G Smiley, Frances M Still, Joshua Kavaler
Department of Biology, Colby College, Waterville, Maine, USA.
Developmental dynamics : an official publication of the American Association of Anatomists 2011 JulThe transcription factor D-Pax2 is required for the correct differentiation of several cell types in Drosophila sensory systems. While the regulation of its expression in the developing eye has been well studied, little is known about the mechanisms by which the dynamic pattern of D-Pax2 expression in the external sensory organs is achieved. Here we demonstrate that early activation of D-Pax2 in the sensory organ lineage and its maintenance in the trichogen and thecogen cells are governed by separate enhancers. Furthermore, the initial activation is controlled in part by proneural proteins whereas the later maintenance expression is regulated by a positive feedback loop. Copyright © 2011 Wiley-Liss, Inc.
Seth A Johnson, Katharine J Harmon, Sarah G Smiley, Frances M Still, Joshua Kavaler. Discrete regulatory regions control early and late expression of D-Pax2 during external sensory organ development. Developmental dynamics : an official publication of the American Association of Anatomists. 2011 Jul;240(7):1769-78
PMID: 21644243
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