Inorganic nanoparticles for enhanced photodynamic cancer therapy.

Shih-Hsun Cheng, Leu-Wei Lo

Division of Medical Engineering Research, National Health Research Institutes, Taiwan.

Current drug discovery technologies 2011 Sep

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Photodynamic therapy (PDT) in cancer treatment uses photosensitizers to generate singlet oxygen followed by photoirradiation. The efficacy of PDT is greatly determined by the dosimetry of activation light and the photosensitizer (PS), modulating the photodynamic reaction at depth in diseased tissue. Development of nano-formulated photosensitizer has emerged as a promising field because of the biocompatibility and the accessibility for multi-functionalization of nanoparticles. In this review, we summarize the contemporary progress in use of inorganic nanoparticles for improvement of PDT in cancer therapeutics.

Citation

Shih-Hsun Cheng, Leu-Wei Lo. Inorganic nanoparticles for enhanced photodynamic cancer therapy. Current drug discovery technologies. 2011 Sep;8(3):250-68