Jia Lin, Ding Zhi Fang, Juan Du, Sarah Shigdar, Li Ying Xiao, Xue Dong Zhou, Wei Duan
Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, and State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, PR China.
Annals of nutrition & metabolism 2011Changes in lipid profiles have been shown to be associated with diet and apolipoprotein (APO) polymorphisms. Therefore, 2 polymorphisms, i.e. APOA5-1131T>C and APOC3-482C>T, and serum lipids were examined in a Chinese healthy young population with high-carbohydrate/low-fat (HC/LF) diet intervention. After a wash-out diet for 7 days, 56 young adults (22.89 ± 1.80 years) received the HC/LF diet for 6 days. Body mass index (BMI) and fasting serum lipid profiles at baseline, after the wash-out diet, and after the HC/LF diet were measured. APOA5-1131C carriers had higher triglyceride (TG) and TG-rich lipoprotein TG (TRL-TG) levels at baseline and after the HC/LF diet, though this mainly corresponded to the female cohort. APOC3-482T carriers had higher TRL-TG levels following the wash-out and HC/LF diets, but these were not directly attributable to a single gender. Both polymorphisms may play an important role in the elevated TG and TRL-TG levels induced by the HC/LF diet, especially in females, thus indicating a potential dietary prevention of coronary heart disease in this Chinese cohort. Copyright © 2011 S. Karger AG, Basel.
Jia Lin, Ding Zhi Fang, Juan Du, Sarah Shigdar, Li Ying Xiao, Xue Dong Zhou, Wei Duan. Elevated levels of triglyceride and triglyceride-rich lipoprotein triglyceride induced by a high-carbohydrate diet is associated with polymorphisms of APOA5-1131T>C and APOC3-482C>T in Chinese healthy young adults. Annals of nutrition & metabolism. 2011;58(2):150-7
PMID: 21646779
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