Increased availability of endogenous and dietary oleic acid contributes to the upregulation of cardiac fatty acid oxidation.

Pawel Dobrzyn, Aleksandra Pyrkowska, Magdalena Jazurek, Agnieszka Dobrzyn

Laboratory of Cell Signaling and Metabolic Disorders, Nencki Institute of Experimental Biology, Warsaw, Poland.

Mitochondrion 2012 Jan

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In the present study, we tested the hypothesis that cardiac substrate utilization is affected by oleic acid originating from the endogenous conversion of stearate by stearoyl-CoA desaturase and from the diet. Here, we show that the cardiac oleate content is increased in tristearate (TS)- and trioleate (TO)-fed rats when compared with chow-fed rats. TS or TO feeding increases mitochondrial fatty acid oxidation via activation of expression of the oxidative genes, activation of the AMP-activated protein kinase pathway, and a decrease in glucose uptake. These results suggest that oleic acid, both dietary and de novo synthesized, affects substrate utilization in the heart. Furthermore, our data show that the endogenous synthesis of oleate in the heart can compensate for a deficiency of this fatty acid in the diet. Copyright © 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

Citation

Pawel Dobrzyn, Aleksandra Pyrkowska, Magdalena Jazurek, Agnieszka Dobrzyn. Increased availability of endogenous and dietary oleic acid contributes to the upregulation of cardiac fatty acid oxidation. Mitochondrion. 2012 Jan;12(1):132-7