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Altered hepatocellular focus was histopathologically observed in the liver of a 6-week-old Sprague-Dawley rat. The hepatocytes within this lesion had diffusely eosinophilic cytoplasm with scattered basophilia and slightly enlarged nuclei with prominent nucleoli. Based on these cytological characteristics, the lesion of these hepatocytes was classified as an amphophilic focus. This is the first report to describe spontaneous amphophilic focus in a young rat. Copyright © 2011 Elsevier GmbH. All rights reserved.


Hiroko Sato, Tetsuya Sakairi, Shiro Takagi, Kazuyuki Kitamura. Spontaneous amphophilic focus in the liver of a young Sprague-Dawley rat. Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie. 2013 Jan;65(1-2):35-7

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PMID: 21665447

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