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As an analog to the endothelium situated next to the vascular smooth muscle, the epithelium is emerging as an important regulator of smooth muscle contraction in many vital organs/tissues by interacting with other cell types and releasing epithelium-derived factors, among which prostaglandins have been demonstrated to play a versatile role in governing smooth muscle contraction essential to the physiological and pathophysiological processes in a wide range of organ systems.

Citation

Ye Chun Ruan, Wenliang Zhou, Hsiao Chang Chan. Regulation of smooth muscle contraction by the epithelium: role of prostaglandins. Physiology (Bethesda, Md.). 2011 Jun;26(3):156-70

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PMID: 21670162

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