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To determine the role of gene expression of Wnt signal pathway in the pathogenesis of familial aggregated hypertension. The patients having directly related family members for more than three generations suffering from hypertension were enlisted in the hypertension group, and healthy individuals served as control group. The real-time polymerase chain reaction (PCR) gene array was used to detect the expression of functional classification genes of Wnt signal pathway in peripheral blood, with standard value deviated>2.0 from hypertension group/control group as differential genes. When hypertension group was compared with the control group, there were 6 differentially expressed genes, with 5 genes up-regulated, including Bcl-9, microphthalmia associated transcription factor (Mitf), secreted frizzled-related protein-1 (Sfrp-1), Wnt inhibiting factor-1 (Wif-1) and ribosomal protein-l13a (Rp-l13a). There was 1 gene down-regulated, i.e. dickkopf homolog-3 (Dkk-3). The result of this study suggested that the Wnt signal pathway may be related to the occurrence and development of the familial aggregated hypertension.


Po Zhang, Zhi-lu Wang, Shou-lan Shi, Zeng-ying Wu, Jian-wen Xiong, Xiao-fang Yang, Ji-lin Ma. A study on expression of Wnt signal pathway gene in familial aggregated hypertension]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. 2011 Jun;23(6):349-51

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PMID: 21672383

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