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A cellular factor binds to the herpes simplex virus type 1 transactivator Vmw65 and is required for Vmw65-dependent protein-DNA complex assembly with Oct-1.
P Xiao, J P Capone
Molecular and cellular biology 1990 Sep
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The herpes simplex virus transactivator Vmw65 assembles into a multicomponent protein-DNA complex along with the octamer binding protein Oct-1. Using affinity chromatography on columns conjugated with purified Vmw65 fusion protein expressed in Escherichia coli, we demonstrate that a cellular factor, distinct from Oct-1, binds to Vmw65 in the absence of target DNA and is necessary for Vmw65-mediated complex assembly with Oct-1.
Citation
P Xiao, J P Capone.
A cellular factor binds to the herpes simplex virus type 1 transactivator Vmw65 and is required for Vmw65-dependent protein-DNA complex assembly with Oct-1.
Molecular and cellular biology.
1990 Sep;10(9):4974-7
Mesh Tags
Base Sequence
Cell Transformation, Viral
DNA Probes
DNA-Binding Proteins
HeLa Cells
Host Cell Factor C1
Humans
Molecular Sequence Data
Octamer Transcription Factor-1
Promoter Regions, Genetic
Simplexvirus
Trans-Activators
Transcription Factors
Substances
DNA Probes
DNA-Binding Proteins
HCFC1 protein, human
Host Cell Factor C1
Octamer Transcription Factor-1
POU2F1 protein, human
Trans-Activators
Transcription Factors
PMID: 2167442
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