Department of Pathology, University of North Carolina, Chapel Hill, NC 27599-7525, USA. cmack@med.unc.edu
Arteriosclerosis, thrombosis, and vascular biology 2011 JulExtensive studies over the last 30 years have demonstrated that vascular smooth muscle cell (SMC) differentiation and phenotypic modulation is controlled by a dynamic array of environmental cues. The identification of the signaling mechanisms by which these environmental cues regulate SMC phenotype has been more difficult because of our incomplete knowledge of the transcription mechanisms that regulate SMC-specific gene expression. However, recent advances in this area have provided significant insight, and the goal of this review is to summarize the signaling mechanisms by which extrinsic cues control SMC differentiation.
Christopher P Mack. Signaling mechanisms that regulate smooth muscle cell differentiation. Arteriosclerosis, thrombosis, and vascular biology. 2011 Jul;31(7):1495-505
PMID: 21677292
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