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The first highly selective and sensitive fluorescent probe Z1 for detection of carbonic anhydrase IX (CA IX) over isoforms CA I and CA II was developed. As demonstrated, Z1 worked effectively in both enzymatic systems and living hypoxia cells.

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Shenyi Zhang, Chunmei Yang, Weiqiang Lu, Jin Huang, Weiping Zhu, Honglin Li, Yufang Xu, Xuhong Qian. A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging. Chemical communications (Cambridge, England). 2011 Aug 7;47(29):8301-3

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PMID: 21681333

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