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The first highly selective and sensitive fluorescent probe Z1 for detection of carbonic anhydrase IX (CA IX) over isoforms CA I and CA II was developed. As demonstrated, Z1 worked effectively in both enzymatic systems and living hypoxia cells.

Citation

Shenyi Zhang, Chunmei Yang, Weiqiang Lu, Jin Huang, Weiping Zhu, Honglin Li, Yufang Xu, Xuhong Qian. A highly selective space-folded photo-induced electron transfer fluorescent probe for carbonic anhydrase isozymes IX and its applications for biological imaging. Chemical communications (Cambridge, England). 2011 Aug 7;47(29):8301-3

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PMID: 21681333

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