Khaled Husain, Elizabeth Thomas, Zeinab Demerdash, Susan Alexander
Department of Paediatric Gastroentrology and Hepatology, Ministry of Health, Kuwait.
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2011 JunIn this case report we describe a case of mediastinal ganglioneuroblastoma-secreting vasoactive intestinal peptide (VIP), causing secretory diarrhoea in an 18-month-old child. An 18-month-old girl presented with a 2-month history of diarrhoea, abdominal distension and weight loss. Investigations revealed secretory diarrhoea with hypokalaemia, hyponatraemia and hypochloraemia and metabolic acidosis. Her stool output was 2.5-3.lday(-1) with increased stool sodium. VIP levels were strikingly high with normal glucagon and gastrin levels. X-ray of the chest revealed a well-defined mass in the right upper zone with tracheal shift, which was confirmed with computed tomography (CT) of the chest. The mass was resected and the patient became asymptomatic. This case shows that secretory diarrhoea caused by VIP and produced by ganglioneuroblastoma indicates a favourable prognosis, provided it is resectable. Copyright © 2010. Published by Elsevier Ltd.
Khaled Husain, Elizabeth Thomas, Zeinab Demerdash, Susan Alexander. Mediastinal ganglioneuroblastoma-secreting vasoactive intestinal peptide causing secretory diarrhoea. Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology. 2011 Jun;12(2):106-8
PMID: 21684485
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