Eisosome-driven plasma membrane organization is mediated by BAR domains.

Natasza E Ziółkowska, Lena Karotki, Michael Rehman, Juha T Huiskonen, Tobias C Walther

Max Planck Institute of Biochemistry, Organelle Architecture and Dynamics, Martinsried, Germany.

Nature structural & molecular biology 2011 Jul

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Plasma membranes are organized into domains of different protein and lipid composition. Eisosomes are key complexes for yeast plasma membrane organization, containing primarily Pil1 and Lsp1. Here we show that both proteins consist mostly of a banana-shaped BAR domain common to membrane sculpting proteins, most similar to the ones of amphiphysin, arfaptin 2 and endophilin 2. Our data reveal a previously unrecognized family of BAR-domain proteins involved in plasma membrane organization.

Citation

Natasza E Ziółkowska, Lena Karotki, Michael Rehman, Juha T Huiskonen, Tobias C Walther. Eisosome-driven plasma membrane organization is mediated by BAR domains. Nature structural & molecular biology. 2011 Jul;18(7):854-6