The MXCXXC class of metallochaperone proteins: model studies.

Michal S Shoshan, Edit Y Tshuva

Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalm, Israel.

Chemical Society reviews 2011 Nov

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Transition metal ions can be both beneficial and harmful to biological systems if not carefully regulated. A family of proteins that include a conserved sequence in their binding site of MXCXXC is responsible for delivery and homeostasis of different metals. Model studies present an effective tool for studying the parameters governing metal affinity, selectivity and other mechanistic aspects. Small-molecule, peptide-based, and advanced models will be presented, as well as functional models of potential industrial applications. This journal is © The Royal Society of Chemistry 2011