CsrA and TnaB coregulate tryptophanase activity to promote exotoxin-induced killing of Caenorhabditis elegans by enteropathogenic Escherichia coli.

Shantanu Bhatt, Akwasi Anyanful, Daniel Kalman

Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30329, USA.

Journal of bacteriology 2011 Sep

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Enteropathogenic Escherichia coli(EPEC) requires the tnaA-encoded enzyme tryptophanase and its substrate tryptophan to synthesize diffusible exotoxins that kill the nematode Caenorhabditis elegans. Here, we demonstrate that the RNA-binding protein CsrA and the tryptophan permease TnaB coregulate tryptophanase activity, through mutually exclusive pathways, to stimulate toxin-mediated paralysis and killing of C. elegans.

Citation

Shantanu Bhatt, Akwasi Anyanful, Daniel Kalman. CsrA and TnaB coregulate tryptophanase activity to promote exotoxin-induced killing of Caenorhabditis elegans by enteropathogenic Escherichia coli. Journal of bacteriology. 2011 Sep;193(17):4516-22