Isolation and biological evaluation of jatrophane diterpenoids from Euphorbia dendroides.

Institute of Chemistry, Technology and Metallurgy, Center for Chemistry, University of Belgrade, Njegoševa 12, 11001 Belgrade, Serbia. aljancic@chem.bg.ac.rs

Journal of natural products 2011 Jul 22

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From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multi-drug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.

Citation

Ivana S Aljancić, Milica Pesić, Slobodan M Milosavljević, Nina M Todorović, Milka Jadranin, Goran Milosavljević, Dragan Povrenović, Jasna Banković, Nikola Tanić, Ivanka D Marković, Sabera Ruzdijić, Vlatka E Vajs, Vele V Tesević. Isolation and biological evaluation of jatrophane diterpenoids from Euphorbia dendroides. Journal of natural products. 2011 Jul 22;74(7):1613-20