Polymorphisms in isoniazid and prothionamide resistance genes of the Mycobacterium tuberculosis complex.

Michaela Projahn, Claudio U Köser, Susanne Homolka, David K Summers, John A C Archer, Stefan Niemann

Molecular Mycobacteriology, Research Center Borstel, Parkallee 1, 23845 Borstel, Germany.

Antimicrobial agents and chemotherapy 2011 Sep

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Sequence analyses of 74 strains that encompassed major phylogenetic lineages of the Mycobacterium tuberculosis complex revealed 10 polymorphisms in mshA (Rv0486) and four polymorphisms in inhA (Rv1484) that were not responsible for isoniazid or prothionamide resistance. Instead, some of these mutations were phylogenetically informative. This genetic diversity must be taken into consideration for drug development and for the design of molecular tests for drug resistance.

Citation

Michaela Projahn, Claudio U Köser, Susanne Homolka, David K Summers, John A C Archer, Stefan Niemann. Polymorphisms in isoniazid and prothionamide resistance genes of the Mycobacterium tuberculosis complex. Antimicrobial agents and chemotherapy. 2011 Sep;55(9):4408-11