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Nuclear Editing of mRNA 3'-UTRs.
Ling-Ling Chen, Gordon G Carmichael
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, 200031 Shanghai, China. linglingchen@sibcb.ac.cn
Current topics in microbiology and immunology 2012Sizes of these terms reflect their relevance to your search.
Hundreds of human genes express mRNAs that contain inverted repeat sequences within their 3'-UTRs. When expressed, these sequences can be promiscuously edited by ADAR enzymes, leading to the retention of mRNAs in nuclear paraspeckles. Here we discuss how this retention system can be used to regulate gene expression.
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Ling-Ling Chen, Gordon G Carmichael. Nuclear Editing of mRNA 3'-UTRs. Current topics in microbiology and immunology. 2012;353:111-21
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PMID: 21725897
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