Francesca Esposito, Luca Zinzula, Andrea Maxia, Enzo Tramontano, Cinzia Sanna
Department of Applied Sciences in Biosystems, University of Cagliari, Cagliari, Italy.
Natural product research 2011 JulThe hydroalcoholic extract obtained from the seeds of Casimiroa edulis cultivated in Sardinia (Italy) have been assayed on the two enzymatic-associated activities of the HIV-1 reverse transcriptase (RT), the RNA-dependent DNA polymerase (RDDP) and the ribonuclease H. In biochemical assays, the extract inhibited both activities in a dose-dependent manner, showing a 10-fold more potent inhibition of the HIV-1 RT RDDP activity. Furthermore, the extract was cytotoxic on K562 cell replication.
Francesca Esposito, Luca Zinzula, Andrea Maxia, Enzo Tramontano, Cinzia Sanna. Inhibition of HIV-1 reverse transcriptase associated activities by the hydroalcoholic extract of Casimiroa edulis seeds. Natural product research. 2011 Jul;25(11):1067-73
PMID: 21726129
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