Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins.

Jiang Qian, Chananat Klomsiri, Marcus W Wright, S Bruce King, Allen W Tsang, Leslie B Poole, Cristina M Furdui

Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA.

Chemical communications (Cambridge, England) 2011 Aug 28

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Facile, two-step synthesis and kinetic characterization of new chemical probes for selective labeling of sulfenic acid (-SOH) in proteins are presented. The synthesis route relies on the simple and highly efficient Michael addition of thiol containing tags or linkers to 4-cyclopentene-1,3-dione, the unsaturated derivative of 1,3-cyclopentanedione.

Citation

Jiang Qian, Chananat Klomsiri, Marcus W Wright, S Bruce King, Allen W Tsang, Leslie B Poole, Cristina M Furdui. Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins. Chemical communications (Cambridge, England). 2011 Aug 28;47(32):9203-5