Jyothi Dhuguru, Chirag Gheewala, N S Saleesh Kumar, James N Wilson
Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, Florida 33124, USA.
Organic letters 2011 Aug 19Aryl pyrimidones are pharmacologically relevant compounds whose optical properties have only been partially explored. We report the synthesis and optical characterization of a series of aryl- and diaryl-2(1H)-pyrimidones. The electronic transitions of these chromophores are modulated by the extent of conjugation between the pendant phenyl ring and the pyrimidone core as well as the presence of electron-donating auxochromes. Monoprotonation of the pyrimidone ring results in large hyperchromic and bathochromic shifts as well as switching of fluorescence making these phenyl pyrimidones of interest as sensory materials. © 2011 American Chemical Society
Jyothi Dhuguru, Chirag Gheewala, N S Saleesh Kumar, James N Wilson. Highly chromic, proton-responsive phenyl pyrimidones. Organic letters. 2011 Aug 19;13(16):4188-91
PMID: 21790121
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