Fludrocortisone improves nausea in children with orthostatic intolerance (OI).

John E Fortunato, Hossam A Shaltout, Megan M Larkin, Peter C Rowe, Debra I Diz, Kenneth L Koch

Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Wake Forest University School of Medicine, Winston-Salem, NC, USA. jfortuna@wfubmc.edu

Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2011 Dec

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INTRODUCTION/RESULTS: In 17 patients, chronic idiopathic nausea was associated with orthostatic intolerance (OI) by abnormal tilt table tests (88%) or gastric dysrhythmias (71%). After fludrocortisone treatment, there was >26% nausea improvement in 71%, 1-25% in 6%, and no improvement in 24%. In six subjects, EGGs repeated after >50% nausea improvement all remained to be abnormal, suggesting nausea is independent of gastric dysrhythmias. Association of EGG abnormalities and OI in this subset of nausea patients suggests a generalized disturbance of autonomic regulation.

Citation

John E Fortunato, Hossam A Shaltout, Megan M Larkin, Peter C Rowe, Debra I Diz, Kenneth L Koch. Fludrocortisone improves nausea in children with orthostatic intolerance (OI). Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2011 Dec;21(6):419-23