Sec14l3 is specifically expressed in mouse airway ciliated cells.

Lihua Shan, Shinobu Noritake, Masatoshi Fujiwara, Satoshi Asano, Chikako Yoshida-Noro, Nobuhiro Noro, Keizo Yamashita, Takao Kawakami

GlaxoSmithKline K.K., Tokyo, Japan.

Inflammation 2012 Apr

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Airway epithelium is a key component for airway integrity. Previously, we found that expression of the Sec14l3 gene that encodes a 45-kDa secretory protein is inversely associated with the progression of experimentally induced airway inflammation and degeneration/necrosis of alveolar epithelium. In this report, using in situ hybridization we demonstrated that the ciliated cells in mouse lung selectively express Sec14l3 mRNA. In a three-dimensional culture of mouse tracheal epithelial cells, levels of the Sec14l3 mRNA correlated with the differentiation of ciliated cells. Intranasal infection of adult mice with influenza virus resulted in a 20-fold, progressive decrease in Sec14l3 mRNA expression over 10 days post infection. These results enhance the potential value of Sec14l3 as a ciliated epithelial cell-specific biomarker for the progression of airway inflammations such as airway viral infection and asthma.

Citation

Lihua Shan, Shinobu Noritake, Masatoshi Fujiwara, Satoshi Asano, Chikako Yoshida-Noro, Nobuhiro Noro, Keizo Yamashita, Takao Kawakami. Sec14l3 is specifically expressed in mouse airway ciliated cells. Inflammation. 2012 Apr;35(2):702-12