Multidrug resistance-associated proteins and their roles in multidrug resistance].

Hui Zhang, Li-wu Fu

State Key Laboratory of Oncology in South China, Cancer Center Sun Yat-sen University, Guangzhou 510060, China.

Yao xue xue bao = Acta pharmaceutica Sinica 2011 May

filter terms:

Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. Multidrug resistance-associated proteins (MRPs) play an important role in the process of MDR. As an ATP-binding cassette (ABC) transporter superfamily, MRPs are selective and specific drug efflux pumps. In this paper, physiological characteristics, structural characteristics and resistance profile of MRPs and the associated reversal studies are reviewed.

Citation

Hui Zhang, Li-wu Fu. Multidrug resistance-associated proteins and their roles in multidrug resistance]. Yao xue xue bao = Acta pharmaceutica Sinica. 2011 May;46(5):479-86