Fragrance material review on ethylene brassylate.

A toxicologic and dermatologic review of ethylene brassylate when used as a fragrance ingredient is presented. Ethylene brassylate is a member of the fragrance structural group macrocyclic lactone and lactide derivatives. The fragrance ingredient described herein is one of 12 structurally diverse C14, C15, and C16 compounds that include (7) saturated mono-and (2) saturated di-ester lactones and (3) unsaturated lactones. For the latter, the double bond is not adjacent to (in conjugation with) the ester group. This review contains a detailed summary of all available toxicology and dermatology papers that are related to ethylene brassylate and is not intended as a stand-alone document. Available data were evaluated, then summarized, and includes: physical properties; acute toxicity; skin irritation; skin sensitization; elicitation; phototoxicity; repeated dose; and genotoxicity data. A safety assessment of the entire macrocyclic lactone and lactide derivatives will be published simultaneously with this document. Please refer to Belsito et al. (2011) for an overall assessment of the safe use of this material and all macrocyclic lactone and lactide derivatives in fragrances. Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Hanifin, J.H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2011. A toxicologic and dermatologic assessment of macrocylic lactone and lactide derivatives when used as fragrance ingredients. Copyright © 2011. Published by Elsevier Ltd.

Citation

D McGinty, C S Letizia, A M Api. Fragrance material review on ethylene brassylate. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011 Dec;49 Suppl 2:S174-82

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PMID: 21801781

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