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Pseudoacromegaly is a condition characterized by cutaneous manifestations of growth hormone excess but with normal growth hormone levels. This is described in patients with severe insulin resistance, pachydermoperiostitis, burnt out acromegaly and with intake of drugs like Minoxidil. Severe thyroid hormone deficiency rarely present with similar picture and the issue is further complicated in presence of pituitary hyperplasia. We report an unusual presentation of primary hypothyroidism with pseudoacromegaly and thyrotroph hyperplasia mimicking a pituitary macroadenoma. The thyrotroph hyperplasia resolved completely with levothyroxine therapy.


K V S Hari Kumar, Altamash Shaikh, Irfan Anwar, P Prusty. Primary hypothyroidism presenting as pseudoacromegaly. Pituitary. 2012 Dec;15 Suppl 1:S49-52

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PMID: 21805092

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