Limonoids from Meliaceae with lipid peroxidation inhibitory activity.

Robert G Fowles, Baldwin S Mootoo, Russel S Ramsewak, William F Reynolds, Muraleedharan G G Nair

Department of Agricultural, Food and Nutritional Science, T6G 2P5, University of Alberta, Edmonton, Alberta, Canada.

Natural product communications 2011 Jun

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In this study the antioxidant activity of natural limonoids from Meliaceae swietenolide (1), 3,6-O,O-diacetylswietenolide (2), swietenine (3), swietemahonin G (4) and 2-hydroxyswietenine (5) were investigated along with the semi-synthetic analogues (6-25) of compounds 1, 3-4. Lipid peroxidation (LPO) inhibitory assays revealed 85.6, 13.3, 77.3, 61.2 and 24.6% inhibition for the natural compounds 1-5. Excellent antioxidant activity was seen for the semi-synthetic analogues 10 (98.3%), 16-17, 21-22 and 25 (100%), which were more active than the positive controls BHA (91.3%) and TBHQ (95.7%).

Citation

Robert G Fowles, Baldwin S Mootoo, Russel S Ramsewak, William F Reynolds, Muraleedharan G G Nair. Limonoids from Meliaceae with lipid peroxidation inhibitory activity. Natural product communications. 2011 Jun;6(6):785-7