Limonoids from Meliaceae with lipid peroxidation inhibitory activity.
Robert G Fowles, Baldwin S Mootoo, Russel S Ramsewak, William F Reynolds, Muraleedharan G G Nair
Department of Agricultural, Food and Nutritional Science, T6G 2P5, University of Alberta, Edmonton, Alberta, Canada.
Natural product communications 2011 JunIn this study the antioxidant activity of natural limonoids from Meliaceae swietenolide (1), 3,6-O,O-diacetylswietenolide (2), swietenine (3), swietemahonin G (4) and 2-hydroxyswietenine (5) were investigated along with the semi-synthetic analogues (6-25) of compounds 1, 3-4. Lipid peroxidation (LPO) inhibitory assays revealed 85.6, 13.3, 77.3, 61.2 and 24.6% inhibition for the natural compounds 1-5. Excellent antioxidant activity was seen for the semi-synthetic analogues 10 (98.3%), 16-17, 21-22 and 25 (100%), which were more active than the positive controls BHA (91.3%) and TBHQ (95.7%).
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Robert G Fowles, Baldwin S Mootoo, Russel S Ramsewak, William F Reynolds, Muraleedharan G G Nair. Limonoids from Meliaceae with lipid peroxidation inhibitory activity. Natural product communications. 2011 Jun;6(6):785-7
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PMID: 21815411
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