Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells.

Jeong Seon Yoon, Eun Ju Jeong, Hyekyung Yang, Seung Hyun Kim, Sang Hyun Sung, Young Choong Kim

College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea.

Journal of enzyme inhibition and medicinal chemistry 2012 Aug

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The methanolic extract of Dictamnus dasycarpus root barks afforded one new glycosidic quinoline alkaloid, 3-[1β-hydroxy-2-(β-D-glucopyranosyloxy)-ethyl)-4-methoxy-2(1H)-quinolinone (1), together with nine known compounds, preskimmianine (2), 8-methoxy-N-methylflindersine (3), dictamine (4), γ-fagarine (5), halopine (6), skimmianine (7), dictangustine-A (8), iso-γ-fagarine (9), isomaculosidine (10). The isolated alkaloids significantly inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. Among them, compounds 3 and 7 showed the most potent inhibitory activities on LPS-induced NO production.]

Citation

Jeong Seon Yoon, Eun Ju Jeong, Hyekyung Yang, Seung Hyun Kim, Sang Hyun Sung, Young Choong Kim. Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells. Journal of enzyme inhibition and medicinal chemistry. 2012 Aug;27(4):490-4