Antiplasmodial indole alkaloids from Leuconotis griffithii.

Alfarius E Nugroho, Yusuke Hirasawa, Wong Chin Piow, Toshio Kaneda, A Hamid A Hadi, Osamu Shirota, Wiwied Ekasari, Aty Widyawaruyanti, Hiroshi Morita

Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.

Journal of natural medicines 2012 Apr

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A new indole alkaloid, leucoridine A N-oxide (1), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii. Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity against Plasmodium falciparum 3D7 of indole alkaloids isolated from L. griffithii was investigated.

Citation

Alfarius E Nugroho, Yusuke Hirasawa, Wong Chin Piow, Toshio Kaneda, A Hamid A Hadi, Osamu Shirota, Wiwied Ekasari, Aty Widyawaruyanti, Hiroshi Morita. Antiplasmodial indole alkaloids from Leuconotis griffithii. Journal of natural medicines. 2012 Apr;66(2):350-3