Brominated aliphatic hydrocarbons and sterols from the sponge Xestospongia testudinaria with their bioactivities.

Xuefeng Zhou, Yanan Lu, Xiuping Lin, Bin Yang, Xianwen Yang, Yonghong Liu

Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.

Chemistry and physics of lipids 2011 Oct

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Four brominated aliphatic hydrocarbons (1-4), including a novel brominated ene-tetrahydrofuran named as mutafuran H (1), and five sterols (5-9) were isolated from the South China Sea sponge Xestospongia testudinaria. The structure of 1 was determined on the basis of NMR ((1)H, (13)C NMR, HSQC, HMBC, (1)H-(1)H COSY, and NOESY), MS, and optical rotation analysis. Known compounds were identified by comparison of their NMR data with those reported in the literature. Compounds 1-4, and 6-9 were evaluated for their toxicity against Artemia salina larvae, and anti-acetylcholinesterase activity. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Citation

Xuefeng Zhou, Yanan Lu, Xiuping Lin, Bin Yang, Xianwen Yang, Yonghong Liu. Brominated aliphatic hydrocarbons and sterols from the sponge Xestospongia testudinaria with their bioactivities. Chemistry and physics of lipids. 2011 Oct;164(7):703-6