Regio- and stereoselective syntheses of the natural product CCR5 antagonist anibamine and its three olefin isomers.

The syntheses of the natural product anibamine and its three olefin isomers have been achieved concisely and efficiently via highly regio- and stereoselective reactions. The crucial steps included a regioselective palladium-catalyzed alkynylation by Sonogashira coupling and a stereoselective Suzuki coupling. Further conformation analyses and in vitro calcium mobilization studies were carried out to characterize the compounds' biological properties.

Citation

Feng Zhang, Saheem Zaidi, Kendra M Haney, Glen E Kellogg, Yan Zhang. Regio- and stereoselective syntheses of the natural product CCR5 antagonist anibamine and its three olefin isomers. The Journal of organic chemistry. 2011 Oct 07;76(19):7945-52

Mesh Tags

Substances

PMID: 21875065

search → result