Actin stress fiber retraction and aggresome formation is a common cellular response to actin toxins.

Sayaka Kazami, Takeo Usui, Hiroyuki Osada

Chemical Library Validation Team, Chemical Biology Core Facility, RIKEN Advanced Science Institute, Saitama.

Bioscience, biotechnology, and biochemistry 2011

filter terms:

F-actin-stabilizing drugs induce actin aggresome formation. In this study, we found that an actin-depolymerizing drug, latrunculin A (LatA), induced actin aggresomes. Actin stress fibers were retracted and disappeared in minutes, but a large aggresome formed in consequence of LatA treatment. Because cytochalasin D and mycalolide also induced aggresome formation, these results suggest that actin aggresome formation is a common cellular response to actin toxins.

Citation

Sayaka Kazami, Takeo Usui, Hiroyuki Osada. Actin stress fiber retraction and aggresome formation is a common cellular response to actin toxins. Bioscience, biotechnology, and biochemistry. 2011;75(9):1853-5