Sayaka Kazami, Takeo Usui, Hiroyuki Osada
Chemical Library Validation Team, Chemical Biology Core Facility, RIKEN Advanced Science Institute, Saitama.
Bioscience, biotechnology, and biochemistry 2011F-actin-stabilizing drugs induce actin aggresome formation. In this study, we found that an actin-depolymerizing drug, latrunculin A (LatA), induced actin aggresomes. Actin stress fibers were retracted and disappeared in minutes, but a large aggresome formed in consequence of LatA treatment. Because cytochalasin D and mycalolide also induced aggresome formation, these results suggest that actin aggresome formation is a common cellular response to actin toxins.
Sayaka Kazami, Takeo Usui, Hiroyuki Osada. Actin stress fiber retraction and aggresome formation is a common cellular response to actin toxins. Bioscience, biotechnology, and biochemistry. 2011;75(9):1853-5
PMID: 21897009
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