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A mathematical model is proposed for processive primer extension by eukaryotic DNA primase. The model uses available experimental data to predict rate constants for the dynamic behavior of primase activity as a function of NTP concentration. The model also predicts some data such as the binding affinities of the primase for the DNA template and for the RNA primer.

Citation

Ping Xie. A model for dynamics of primer extension by eukaryotic DNA primase. European biophysics journal : EBJ. 2011 Oct;40(10):1157-65

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PMID: 21898172

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