Inhibitory effect of sodium hypochlorite and chlorhexidine digluconate in clinical isolates of Sporothrix schenckii.

Isabel Martins Madrid, Antonella Souza Mattei, Rosema Santin, Angelita dos Reis Gomes, Marlete Brum Cleff, Mário Carlos Araújo Meireles

Laboratory of Infectious Diseases, Federal University of Pelotas, Brazil Federal University of Rio Grande do Sul, Brazil.

Mycoses 2012 May

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The susceptibility of Sporothrix schenckii isolates from clinical cases of canine, feline and human sporotrichosis, and from the environment, was evaluated with 4% sodium hypochlorite and 6.6% chlorhexidine digluconate using the broth microdilution, agar diffusion and direct exposure techniques. The minimal inhibitory concentration was smaller than 0.8% for chlorhexidine digluconate and between 8% and 4% for sodium hypochlorite. Inhibition zones were not found in agar diffusion for sodium hypochlorite, and zones averaging 1.9 mm were found for chlorhexidine digluconate. In the direct exposure test, sodium hypochlorite demonstrated best performance at 20 min of contact, as chlorhexidine digluconate presented little antimicrobial activity. © 2011 Blackwell Verlag GmbH.

Citation

Isabel Martins Madrid, Antonella Souza Mattei, Rosema Santin, Angelita dos Reis Gomes, Marlete Brum Cleff, Mário Carlos Araújo Meireles. Inhibitory effect of sodium hypochlorite and chlorhexidine digluconate in clinical isolates of Sporothrix schenckii. Mycoses. 2012 May;55(3):281-5