Yan Huang, Wenxia Zhou, Yongxiang Zhang
Beijing Institute of Pharmacology and Toxicology, Tai Ping Road 27, Beijing 100850, China.
Behavioural brain research 2012 Jan 1In this study, we investigated the performance of BALB/c mice in Morris water maze task under two different illumination (bright and dim light) conditions. The results show that BALB/c mice could not complete the Morris water maze task under bright light (BLC), but performed very well under dim light (DLC). Animals that swam under BLC had a higher serum corticosterone level than those under DLC. Animals pretrained under DLC had a lower serum corticosterone level than those directly exposed to BLC. Our results also show that animals under BLC had a higher level of thigmotaxis (a behavioral anxiety measure during testing) than under DLC. Correlation analysis shows that corticosterone and thigmotaxis levels have a positive correlation with escape latency, indicating that corticosterone and thigmotaxis levels have a negative correlation with learning/memory performance. These results suggest that BALB/c mice have the ability to learn a spatial task; under BLC, they performed poorly owing to a high level of thigmotaxis. Copyright © 2011 Elsevier B.V. All rights reserved.
Yan Huang, Wenxia Zhou, Yongxiang Zhang. Bright lighting conditions during testing increase thigmotaxis and impair water maze performance in BALB/c mice. Behavioural brain research. 2012 Jan 1;226(1):26-31
PMID: 21907245
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