Glucoreceptors located in the brain mediate NPY release induced by hypoglycemia in normal men.

Vittorio Coiro, Riccardo Volpi, Simona Cataldo, Maria Grazia Magotti, Claudio Giumelli, Francesca Russo, Adriano Stella, Paolo Chiodera

Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy. vittorio.coiro@unipr.it

Regulatory peptides 2011 Dec 10

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The NPY secretory pattern after an insulin tolerance test (ITT) (0.15 IU/kg body weight) was evaluated in 8 normal men. They were infused with normal saline (control test), glucose or fructose. Insulin-induced hypoglycemia produced a significant increment in serum NPY in the control test. The infusion of fructose was unable to change the NPY secretory pattern during insulin-induced hypoglycemia. In contrast, the NPY increase during ITT was completely abolished when the concomitant infusion of glucose prevented insulin-induced hypoglycemia. These results exclude a direct role of hyperinsulinemia in the mechanism underlying the stimulation of NPY secretion during ITT. Furthermore, since glucose but not fructose crosses the blood-brain-barrier (BBB), the NPY increase during ITT appears to be generated by low glucose concentrations at the level of glucosensitive areas located inside the brain. Copyright © 2011 Elsevier B.V. All rights reserved.

Citation

Vittorio Coiro, Riccardo Volpi, Simona Cataldo, Maria Grazia Magotti, Claudio Giumelli, Francesca Russo, Adriano Stella, Paolo Chiodera. Glucoreceptors located in the brain mediate NPY release induced by hypoglycemia in normal men. Regulatory peptides. 2011 Dec 10;172(1-3):41-3