One new pregnane glycoside from the seeds of cultivated Brucea javanica.

Jie-Qing Liu, Cui-Fang Wang, Xing-Yao Li, Jian-Chao Chen, Yan Li, Ming-Hua Qiu

State Key Laboratory of Photochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China.

Archives of pharmacal research 2011 Aug

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A new pregnane glycoside, named (20R)-O-(3)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-pregn-5-en-3β,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea javanica. The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells. These results indicate that cultivated B. javanica could replace the wild plant as an antitumor plant resource.

Citation

Jie-Qing Liu, Cui-Fang Wang, Xing-Yao Li, Jian-Chao Chen, Yan Li, Ming-Hua Qiu. One new pregnane glycoside from the seeds of cultivated Brucea javanica. Archives of pharmacal research. 2011 Aug;34(8):1297-300