Differential effects of laminin isoforms on axon and dendrite development in hippocampal neurons.

Eri Fusaoka-Nishioka, Chisei Shimono, Yukimasa Taniguchi, Aki Togawa, Akio Yamada, Eiji Inoue, Hiroshi Onodera, Kiyotoshi Sekiguchi, Toshio Imai

KAN Research Institute, Kobe, Japan.

Neuroscience research 2011 Dec

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Laminins play an important role in neuronal development. However, the effects of each laminin isoform on neurite morphology remain unclear. Here, we examined the effects of particular laminin (LN) isoforms on hippocampal neuron morphology. We found that LN-511 remarkably promoted elongation of both axons and dendrites, but reduced the number of dendrites. LN-511 E8 fragment, which includes the integrin-binding region, promoted axon and dendrite outgrowth and increased the dendrite number, although its effect on axon and dendrite elongation was smaller than that of full-length LN-511. These results suggest that LN-511 regulates axon and dendrite development by integrin-dependent and -independent mechanisms. Copyright Â© 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

Citation

Eri Fusaoka-Nishioka, Chisei Shimono, Yukimasa Taniguchi, Aki Togawa, Akio Yamada, Eiji Inoue, Hiroshi Onodera, Kiyotoshi Sekiguchi, Toshio Imai. Differential effects of laminin isoforms on axon and dendrite development in hippocampal neurons. Neuroscience research. 2011 Dec;71(4):421-6