Quinolone induction of qnrVS1 in Vibrio splendidus and plasmid-carried qnrS1 in Escherichia coli, a mechanism independent of the SOS system.

Ryo Okumura, Chun-Hsing Liao, Mariah Gavin, George A Jacoby, David C Hooper

Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114-2696, USA.

Antimicrobial agents and chemotherapy 2011 Dec

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Plasmid-carried qnrS1 is derived from Vibrio splendidus chromosomal qnrVS1. qnrVS1 transcripts increased 21- to 34-fold with subinhibitory concentrations of ciprofloxacin but much less with mitomycin. No LexA binding sites were upstream of qnrS1 or qnrVS1, and similar induction levels were observed in lexA-positive and lexA-negative Escherichia coli strains with native qnrS1 plasmid pMG306 but not with pUC18-cloned qnrS1 or qnrVS1. Thus, qnrS1 induction by quinolones is independent of the SOS system and requires sequence besides that of the structural gene.

Citation

Ryo Okumura, Chun-Hsing Liao, Mariah Gavin, George A Jacoby, David C Hooper. Quinolone induction of qnrVS1 in Vibrio splendidus and plasmid-carried qnrS1 in Escherichia coli, a mechanism independent of the SOS system. Antimicrobial agents and chemotherapy. 2011 Dec;55(12):5942-5