A case of corpus callosum agenesis presenting with recurrent brief depression.

Agenesis of corpus callosum can have various neuropsychiatric manifestations. Following case report highlights the case of a young man presenting with features of recurrent brief depressive disorder, each lasting for about 3 to 7 days, for over a year. He had history of occasional headache and episodes of swooning attack in between, usually precipitated by emotional events. His neuroimaging revealed agenesis of corpus callosum. He was experiencing swooning attacks as he became aware that some 'unusual' findings were present in his reports. Recurrent brief depression can be a manifestation of this congenital anomaly, and conversion disorder can be present as comorbid diagnosis perhaps due to ignorance and fear of this apparently innocuous congenital malformation.

Citation

Ranjan Bhattacharyya, Debasish Sanyal, Suddhendu Chakraborty, Sumita Bhattacharyya. A case of corpus callosum agenesis presenting with recurrent brief depression. Indian journal of psychological medicine. 2009 Jul;31(2):92-5

PMID: 21938102

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