Regulation of endothelial cell development by ETS transcription factors.

Stryder M Meadows, Candace T Myers, Paul A Krieg

Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, United States.

Seminars in cell & developmental biology 2011 Dec

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The ETS family of transcription factors plays an essential role in controlling endothelial gene expression. Multiple members of the ETS family are expressed in the developing endothelium and evidence suggests that the proteins function, to some extent, redundantly. However, recent studies have demonstrated a crucial non-redundant role for ETV2, as a primary player in specification and differentiation of the endothelial lineage. Here, we review the contribution of ETS factors, and their partner proteins, to the regulation of embryonic vascular development. Copyright © 2011 Elsevier Ltd. All rights reserved.

Citation

Stryder M Meadows, Candace T Myers, Paul A Krieg. Regulation of endothelial cell development by ETS transcription factors. Seminars in cell & developmental biology. 2011 Dec;22(9):976-84