TGF-β1 content in atherosclerotic plaques, TGF-β1 serum concentrations and incident coronary events.

Christian Herder, Wouter Peeters, Astrid Zierer, Dominique P V de Kleijn, Frans L Moll, Mahir Karakas, Michael Roden, Christa Meisinger, Barbara Thorand, Gerard Pasterkamp, Wolfgang Koenig

Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

European journal of clinical investigation 2012 Mar

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We tested the hypothesis that high TGF-β1 content in atherosclerotic plaques and high TGF-β1 serum levels are associated with lower risk of coronary events in two independent prospective studies. In the prospective Athero-Express biobank study, total TGF-β1 plaque levels were measured in 632 atherosclerotic lesions from patients who underwent carotid endarterectomy. In a population-based case-cohort study within the Monitoring of trends and determinants in cardiovascular disease (MONICA)/Cooperative Health Research in the Region of Augsburg (KORA) Augsburg studies, baseline total TGF-β1 serum levels were measured in 333 individuals with and 1728 without incident coronary events. Patients with TGF-β1 content in their plaques above the study median did not have a lower risk of coronary events than patients with lower TGF-β1 levels [adjusted HR (95% CI) 1·46 (0·83-2·53); P = 0·16; mean follow-up 2·6 ± 0·7 years] in the Athero-Express biobank study. Cox proportional hazard models adjusting for age, sex, body mass index, metabolic factors, lifestyle factors and survey did not reveal a significant association between TGF-β1 serum levels and incident coronary events [HR (95% CI) for increasing TGF-β1 tertiles 1·0, 1·22 (0·88-1·68), 1·13 (0·82-1·57); P = 0·47; mean follow-up: 10·8 ± 4·6 years] in the MONICA/KORA Augsburg studies. Our results indicate that high TGF-β1 content in human atherosclerotic plaques and high serum levels of TGF-β1 are not associated with reduced risk of coronary events. © 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation.

Citation

Christian Herder, Wouter Peeters, Astrid Zierer, Dominique P V de Kleijn, Frans L Moll, Mahir Karakas, Michael Roden, Christa Meisinger, Barbara Thorand, Gerard Pasterkamp, Wolfgang Koenig. TGF-β1 content in atherosclerotic plaques, TGF-β1 serum concentrations and incident coronary events. European journal of clinical investigation. 2012 Mar;42(3):329-37