Regio- and chemoselective metalation of arenes and heteroarenes using hindered metal amide bases.

Benjamin Haag, Marc Mosrin, Hiriyakkanavar Ila, Vladimir Malakhov, Paul Knochel

Department Chemie, Ludwig-Maximilians-Universität München, Germany.

Angewandte Chemie (International ed. in English) 2011 Oct 10

filter terms:

The preparation of highly functionalized organometallic compounds can be achieved by direct C-H activation of a broad range of unsaturated substrates using lithium chloride solubilized 2,2,6,6-tetramethylpiperidide bases (TMP(n)MX(m)⋅p LiCl). These are excellent reagents for converting a wide range of aromatic and heterocyclic substrates into valuable organometallic reagents with broad applications in organic synthesis. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation

Benjamin Haag, Marc Mosrin, Hiriyakkanavar Ila, Vladimir Malakhov, Paul Knochel. Regio- and chemoselective metalation of arenes and heteroarenes using hindered metal amide bases. Angewandte Chemie (International ed. in English). 2011 Oct 10;50(42):9794-824