mRNA 3' end processing and more--multiple functions of mammalian cleavage factor I-68.

Marc-David Ruepp, Daniel Schümperli, Silvia M L Barabino

Institute of Cell Biology, University of Bern, Bern, Switzerland.

Wiley interdisciplinary reviews. RNA 2011 Jan-Feb

filter terms:

The formation of defined 3(') ends is an important step in the biogenesis of mRNAs. In eukaryotic cells, all mRNA 3(') ends are generated by endonucleolytic cleavage of primary transcripts in reactions that are essentially posttranscriptional. Nevertheless, 3(') end formation is tightly connected to transcription in vivo, and a link with mRNA export to the cytoplasm has been postulated. Here, we briefly review the current knowledge about the two types of mRNA 3(') end processing reactions, cleavage/polyadenylation and histone RNA processing. We then focus on factors shared between these two reactions. In particular, we discuss evidence for new functions of the mammalian cleavage factor I subunit CF I(m) 68 in histone RNA 3(') processing and in the export of mature mRNAs from the nucleus to the cytoplasm. Copyright © 2010 John Wiley & Sons, Inc.

Citation

Marc-David Ruepp, Daniel Schümperli, Silvia M L Barabino. mRNA 3' end processing and more--multiple functions of mammalian cleavage factor I-68. Wiley interdisciplinary reviews. RNA. 2011 Jan-Feb;2(1):79-91