Possible molecular mechanisms of spontaneous remission in sudden idiopathic hearing loss].

U-R Heinrich, J Brieger, R H Stauber, W J Mann

Hals-, Nasen-, Ohrenklinik und Poliklinik, Universitätsmedizin der Johannes Gutenberg-Universität, Langenbeckstr.1, 55131, Mainz, Deutschland. heinrich@hno.klinik.uni-mainz.de

HNO 2011 Nov

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According to current knowledge, it must be assumed that temporary idiopathic hearing loss and its spontaneous remission are based on mechanical and/or pathological alterations in the inner ear. The causal mechanisms might be based on inter-individual variations. Induced by dose-dependent activators, temporary as well as permanent damage might occur. Sudden hearing loss may be initiated by an increase in the local nitric oxide (NO) concentration. Spontaneous remission, i.e. functional restoration, can be explained by a local decrease in the NO concentration. In this context, regulatory systems such as the gap-junction system, blood vessels or synapses might be affected. In addition, alterations in the hormone level of estrogen and mineralocorticoids, as well as cellular glutathione and vitamin levels, might lead to temporary alterations in the inner ear. Recent experimental findings indicate a role for the shuttle protein Survivin in the spontaneous remission of sudden hearing loss.

Citation

U-R Heinrich, J Brieger, R H Stauber, W J Mann. Possible molecular mechanisms of spontaneous remission in sudden idiopathic hearing loss]. HNO. 2011 Nov;59(11):1103-10