Brain mapping biomarkers of socio-emotional processing in schizophrenia.

Stephan F Taylor, Angus W MacDonald, Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia

Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Road, Ann Arbor, MI 48109-2700, USA. sftaylor@umich.edu

Schizophrenia bulletin 2012 Jan

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The Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative has formed with the expressed intent of identifying constructs and paradigms that would identify biomarkers of psychosis. The manipulation of these biomarkers would serve as targets for treatment interventions. The second phase of CNTRICS consisted of critical discussions evaluating brain mapping (functional neuroimaging and brain electrical activity) paradigms as biomarkers to measure specific constructs. Among the constructs identified in, CNTRICS I was socio-emotional processing, specifically focused on affect recognition. Here, we provide a critical appraisal of the ability of candidate socio-emotional tasks to identify putative biomarkers and recommendations for future directions in this rapidly moving research domain.

Citation

Stephan F Taylor, Angus W MacDonald, Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia. Brain mapping biomarkers of socio-emotional processing in schizophrenia. Schizophrenia bulletin. 2012 Jan;38(1):73-80