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The current study aims to determine the antimutagenic potential of five newly synthesized cyclic compounds against the genotoxic agents sodium azide (NaN₃) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The mutant bacterial tester strains were NaN₃-sensitive Salmonella typhimurium TA1535 and MNNG-sensitive Escherichia coli WP2uvrA. According to the results, all the test compounds showed significant antimutagenic activity. The inhibition rates ranged from 26.05% (Compound 4-1 µg/plate) to 68.54% (Compound 5-0.01 µg/plate) for NaN₃ and from 32.44% (Compound 3-1 µg/plate) to 60.77% (Compound 5-1 µg/plate) for MNNG genotoxicity. Moreover, the mutagenic potential of the test compounds was investigated using the same strains. The results showed that all the test compounds do not have mutagenic potential on the bacterial strains at the tested concentrations. Thus, the findings of the present study give valuable information about chemical prevention from NaN₃ and MNNG genotoxicity.

Citation

Kadir Turhan, S Arda Ozturkcan, Zuhal Turgut, Mehmet Karadayi, Medine Gulluce. Protective properties of five newly synthesized cyclic compounds against sodium azide and N-methyl-N'-nitro-N-nitrosoguanidine genotoxicity. Toxicology and industrial health. 2012 Aug;28(7):605-13

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PMID: 21967842

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