Breaches of the pial basement membrane are associated with defective dentate gyrus development in mouse models of congenital muscular dystrophies.

Jing Li, Miao Yu, Gang Feng, Huaiyu Hu, Xiaofeng Li

Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Neuroscience letters 2011 Nov 7

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A subset of congenital muscular dystrophies (CMDs) has central nervous system manifestations. There are good mouse models for these CMDs that include POMGnT1 knockout, POMT2 knockout and Large(myd) mice with all exhibiting defects in dentate gyrus. It is not known how the abnormal dentate gyrus is formed during the development. In this study, we conducted a detailed morphological examination of the dentate gyrus in adult and newborn POMGnT1 knockout, POMT2 knockout, and Large(myd) mice by immunofluorescence staining and electron microscopic analyses. We observed that the pial basement membrane overlying the dentate gyrus was disrupted and there was ectopia of granule cell precursors through the breached pial basement membrane. Besides these, the knockout dentate gyrus exhibited reactive gliosis in these mouse models. Thus, breaches in the pial basement membrane are associated with defective dentate gyrus development in mouse models of congenital muscular dystrophies. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Citation

Jing Li, Miao Yu, Gang Feng, Huaiyu Hu, Xiaofeng Li. Breaches of the pial basement membrane are associated with defective dentate gyrus development in mouse models of congenital muscular dystrophies. Neuroscience letters. 2011 Nov 7;505(1):19-24