C-Reactive protein-directed immobilization of phosphocholine ligands on a solid surface.

Eunjoo Kim, Hyun-Chul Kim, Se Geun Lee, Sung Jun Lee, Tae-Jung Go, Chul Su Baek, Sang Won Jeong

Nano & Bio Research Division, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 711-873, Korea.

Chemical communications (Cambridge, England) 2011 Nov 21

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The complexes of C-reactive protein (CRP) with its polymerizable phosphocholine ligands adsorbed at the styrene-water interface were polymerized. The molecularly imprinted polymer (MIP) exhibited a binding affinity for CRP comparable to that of immobilized anti-CRP antibody. The determination of human serum CRP using the MIP-based sandwich immunoassay has been demonstrated. This journal is © The Royal Society of Chemistry 2011

Citation

Eunjoo Kim, Hyun-Chul Kim, Se Geun Lee, Sung Jun Lee, Tae-Jung Go, Chul Su Baek, Sang Won Jeong. C-Reactive protein-directed immobilization of phosphocholine ligands on a solid surface. Chemical communications (Cambridge, England). 2011 Nov 21;47(43):11900-2