First report on Ambisome-associated allergic reaction in two Sudanese leishmaniasis patients.

Maowia Mukhtar, Mona Aboud, Musa Kheir, Sahar Bakhiet, Nazik Abdullah, Ahmed Ali, Nadia Hassan, Elwaleed Elamin, Atif Elagib

Institute of Endemic Diseases, University of Khartoum, Sudan. mmukhtar@tropmedicine.org

The American journal of tropical medicine and hygiene 2011 Oct

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Post kala-azar dermal leishmaniasis (PKDL) and mucosal leishmaniasis (ML) are serious clinical forms of leishmaniasis caused by Leishmania donovani parasites in Sudan. Although pentavalent antimonys are used as the first line of treatment of all clinical forms of leishmaniasis, persistent PKDL and ML patients are treated with liposomal amphotericin B (Ambisome) as a second-line drug. In this work, we report the development of allergic reactions by a PKDL and a ML Sudanese patient to Ambisome. The findings warrant future close supervision of patients to be treated with the drug.

Citation

Maowia Mukhtar, Mona Aboud, Musa Kheir, Sahar Bakhiet, Nazik Abdullah, Ahmed Ali, Nadia Hassan, Elwaleed Elamin, Atif Elagib. First report on Ambisome-associated allergic reaction in two Sudanese leishmaniasis patients. The American journal of tropical medicine and hygiene. 2011 Oct;85(4):644-5